Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 9924936, compound

HRID 1796050Notes

Reaction equation

HRID 1796050 reaction equation
C([Sn](CCCC)(CCCC)[C:6]1[N:10]2[CH:11]=[CH:12][C:13]([C:15]([F:18])([F:17])[F:16])=[N:14][C:9]2=[N:8][CH:7]=1)CCC.Br[C:28]1[CH:29]=[CH:30][C:31]([C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)=[N:32][CH:33]=1>>[F:40][C:37]1[CH:36]=[CH:35][C:34]([C:31]2[CH:30]=[CH:29][C:28]([C:6]3[N:10]4[CH:11]=[CH:12][C:13]([C:15]([F:16])([F:17])[F:18])=[N:14][C:9]4=[N:8][CH:7]=3)=[CH:33][N:32]=2)=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 11294484Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)-HCID 221807795-Bromo-2-(4-fluorophenyl)pyridine

Product 1

HCID 9924936HCID 9924936, compound

Procedure

3-Tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine was reacted with 5-bromo-2-(4-fluorophenyl)pyridine by the method of Example 1 to furnish 3-[2-(4-fluorophenyl)pyridin-5-yl]-7-trifluoromethylimidazo[1,2-α]pyrimidine (47mg) as a yellow solid: δH (400 MHz, CDCl3) 7.19-7.25 (2H, m), 7.31 (1H, d, J 7), 7.90-7.97 (2H, m), 8.06-8.11 (2H, m), 8.19 (1H, s), 8.82 (1H, d, J 7), 8.91 (1H, dd, J 2 and 1); m/z (ES+) 358, 359 (M++H).

Sources & evidence

ORD record
ord-4b3eca8c95d24a0992ffb5f54304bc08
Source dataset
uspto-grants-2006_04
Patent number
US07030128B2

Reaction notes

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