huagongshe.com
HRID1796113

反应详情

EQUATION

反应方程式

HRID 1796113 的结构方程式

REACTANTS

反应物

2
结构：CC(F)(F)c1nccc(Cl)n1
HCID22180773

未命名化合物

结构：CC[Si](CC)(CC)OC(C)(C)c1ccn2c(Br)cnc2n1
HCID69559848

未命名化合物

PRODUCTS

生成物

1
结构：CC[Si](CC)(CC)OC(C)(C)c1ccn2c(-c3ccnc(C(C)(F)F)n3)cnc2n1
HCID69560570

未命名化合物

PROCEDURE

实验过程

3-Bromo-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine (567 mg, 1.4 mmol) and 4-chloro-2-(1,1-difluoroethyl)pyrimidine (209 mg, 1.17 mmol) were reacted together as described in Example 39, Step 1. Purification by column chromatography on silica using 3% MeOH/CH2Cl2 gave 3-[2-(1,1-difluoroethyl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine.

WORKUP

后处理

  1. customPurification by column chromatography on silica using 3% MeOH/CH2Cl2