HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(1,1-difluoroethyl)pyrimidine → 3-[2-(1,1-Difluoroethyl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-alpha]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(1,1-difluoroethyl)pyrimidine | HCID 22180773 | — |
| Reactant | 3-Bromo-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-alpha]pyrimidine | HCID 69559848 | — |
| Product | 3-[2-(1,1-Difluoroethyl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-alpha]pyrimidine | HCID 69560570 | — |
Reaction Steps
3-Bromo-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine (567 mg, 1.4 mmol) and 4-chloro-2-(1,1-difluoroethyl)pyrimidine (209 mg, 1.17 mmol) were reacted together as described in Example 39, Step 1. Purification by column chromatography on silica using 3% MeOH/CH2Cl2 gave 3-[2-(1,1-difluoroethyl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030128B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-df26a0f452b84f729f5f244aab7ad252 |
| Source note | uspto-grants-2006_04 |