(R)-2-((S)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid → (S)-2-(1-Fluoro-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid

HRID 1796156Notes

Reaction equation

HRID 1796156 reaction equation
O[C@@H]([C@@H](CCCC1C=CC=CC=1)C(O)=O)C(N1CCOCC1)=O.C[O:25][C:26](=[O:47])[C@@H:27]([CH:37]([F:46])[C:38]([N:40]1[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1)=[O:39])[CH2:28][CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[F:46][CH:37]([C@@H:27]([CH2:28][CH2:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:26]([OH:47])=[O:25])[C:38]([N:40]1[CH2:41][CH2:42][O:43][CH2:44][CH2:45]1)=[O:39]

Participants

3

Reactant 2

HCID 58619483(R)-2-((S)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acidHCID 69619069(S)-2-(1-Fluoro-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid methyl ester

Product 1

HCID 58619495(S)-2-(1-Fluoro-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid

Procedure

It is similarly prepared according to the procedure of (22), but using (S)-2-(1-Fluoro-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid methyl ester (6a).

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-a1d59dfb4a4648dc89d2174a40c439b4
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

Loading…