4-Morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyric acid → 4-Morpholin-4-yl-4-oxo-2-phenylmethanesulfonylmethyl-N-[(S)-1-(5-trifluoromethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-butyramide

HRID 1796163노트

반응식

HRID 1796163 반응식
[N:1]1([C:7](=[O:24])[CH2:8][CH:9]([CH2:13][S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:16])=[O:15])[C:10]([OH:12])=O)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O.[NH2:32][CH:33]([CH2:45][CH3:46])[C@@H:34]([C:36]1[N:40]=[C:39]([C:41]([F:44])([F:43])[F:42])[O:38][N:37]=1)[OH:35]>>[N:1]1([C:7](=[O:24])[CH2:8][CH:9]([CH2:13][S:14]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:16])=[O:15])[C:10]([NH:32][C@H:33]([C:34]([C:36]2[N:40]=[C:39]([C:41]([F:44])([F:43])[F:42])[O:38][N:37]=2)=[O:35])[CH2:45][CH3:46])=[O:12])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 220539874-Morpholin-4-yl-4-oxo-2-benzylsulfonylmethyl-butyric acidHCID 86588340(S)-2-amino-1-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol trifluoroacetate

생성물 1

HCID 586195284-Morpholin-4-yl-4-oxo-2-phenylmethanesulfonylmethyl-N-[(S)-1-(5-trifluoromethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-butyramide

실험 절차

It is similarly prepared according to general procedure given for Example 2 above but using 4-Morpholin-4-yl-4-oxo-2-phenylmethanesulfonylmethyl-butyric acid and (S)-2-Amino-1-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol; compound with trifluoroacetic acid.

후처리

  1. customIt is similarly prepared

출처 및 근거

ORD 기록
ord-9d6d8e404f0e43df98e3d59576e9802c
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030116B2

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