(R)-2-(1-Benzyl-cyclopropylmethyl)-4-morpholin-4-yl-4-oxo-butyric acid → (R)-2-(1-Benzyl-cyclopropylmethyl)-N-[(S)-1-(5-ethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-4-morpholin-4-yl-4-oxo-butyramide

HRID 1796175Notes

Reaction equation

HRID 1796175 reaction equation
[CH2:1]([C:8]1([CH2:11][C@H:12]([CH2:16][C:17]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[O:18])[C:13](O)=[O:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.[NH2:32][CH:33]([CH2:43][CH3:44])[C@@H:34]([C:36]1[N:40]=[C:39]([CH2:41][CH3:42])[O:38][N:37]=1)[OH:35]>>[CH2:1]([C:8]1([CH2:11][C@H:12]([CH2:16][C:17]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[O:18])[C:13]([NH:32][C@H:33]([C:34]([C:36]2[N:40]=[C:39]([CH2:41][CH3:42])[O:38][N:37]=2)=[O:35])[CH2:43][CH3:44])=[O:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 58619525(R)-2-(1-Benzyl-cyclopropylmethyl)-4-morpholin-4-yl-4-oxo-butyric acidHCID 69427127(S)-2-amino-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol trifluoroacetate

Product 1

HCID 58619522(R)-2-(1-Benzyl-cyclopropylmethyl)-N-[(S)-1-(5-ethyl-1,2,4-oxadiazole-3-carbonyl)-propyl]-4-morpholin-4-yl-4-oxo-butyramide

Procedure

It is similarly prepared according to general procedure given for example 10 above but using (R)-2-(1-Benzyl-cyclopropylmethyl)-4-morpholin-4-yl-4-oxo-butyric acid and (S)-2-Amino-1-(5-ethyl-1,2,4-oxadiazol-3-yl)-butan-1-ol; compound with trifluoro-acetic acid.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-ce6e55d3cce14f69b4d6aabba8c28512
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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