Hydrochloric Acid → (R)-4,4,6-Trimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-heptanoic acid [(S)-1-(oxazole-2-carbonyl)-propyl]-amide

HRID 1796180Notes

Reaction equation

HRID 1796180 reaction equation
[NH2:1][C@@H:2]([CH2:10][CH3:11])[C:3]([C:5]1[O:6][CH:7]=[CH:8][N:9]=1)=[O:4].Cl.[CH3:13][C:14]([CH3:33])([CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:15][C@H:16]([CH2:20][C:21]([N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1)=[O:22])[C:17](O)=[O:18]>>[O:6]1[CH:7]=[CH:8][N:9]=[C:5]1[C:3]([C@@H:2]([NH:1][C:17](=[O:18])[C@@H:16]([CH2:20][C:21]([N:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1)=[O:22])[CH2:15][C:14]([CH3:13])([CH3:33])[CH2:29][CH:30]([CH3:31])[CH3:32])[CH2:10][CH3:11])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 58619524(S)-2-Amino-1-oxazol-2-yl-butan-1-oneHCID 58628214(R)-4,4,6-Trimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-heptanoic acid

Product 1

HCID 58619513(R)-4,4,6-Trimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-heptanoic acid [(S)-1-(oxazole-2-carbonyl)-propyl]-amide

Procedure

It is similarly prepared according to the general procedure for Example 10 using (S)-2-Amino-1-oxazol-2-yl-butan-1-one; hydrochloride as the amino component and (R)-4,4,6-Trimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-heptanoic acid as the acidic component but without further oxidation step.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-73aa95f86d924b9680da60fa16d34420
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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