Hydrochloric Acid → 2-(2-Morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid[(s)-1-(oxazole-2-carbonyl)-propyl]-amide

HRID 1796182Notes

Reaction equation

HRID 1796182 reaction equation
[NH2:1][C@@H:2]([CH2:10][CH3:11])[C:3]([C:5]1[O:6][CH:7]=[CH:8][N:9]=1)=[O:4].Cl.[N:13]1([C:19](=[O:34])[CH2:20][CH:21]([CH2:25][CH2:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22](O)=[O:23])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[O:6]1[CH:7]=[CH:8][N:9]=[C:5]1[C:3]([C@@H:2]([NH:1][C:22](=[O:23])[CH:21]([CH2:20][C:19]([N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1)=[O:34])[CH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:10][CH3:11])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 98576732-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic AcidHCID 58619524(S)-2-Amino-1-oxazol-2-yl-butan-1-one

Product 1

HCID 210256562-(2-Morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid[(s)-1-(oxazole-2-carbonyl)-propyl]-amide

Procedure

It is similarly prepared according to the general procedure for Example 10 using (S)-2-Amino-1-oxazol-2-yl-butan-1-one; hydrochloride as the amino component and 2-(2-Morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid as the acidic component but without further oxidation.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-124313ef20d84c6293204ad00b0ba35b
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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