反应详情

2-(Chloromethyl)-1H-benzimidazole (3.32 g, 0.02 mol) and DMAP (0.2 g) in Ac2O (50 ml) were refluxed for 8 h. The excess Ac2O was evaporated under vacuum and the residue was purified by column chromatography (silica, EtOAc:hexanes 2:1, first fraction) to obtain 2.37 g of product 7 (57%)

1. customThe excess Ac2O was evaporated under vacuum
2. customthe residue was purified by column chromatography (silica, EtOAc:hexanes 2:1, first fraction)