Sodium Hydroxide → HCID 23706078, compound

HRID 1796393Notes

Reaction equation

HRID 1796393 reaction equation
[C:1]1([C:6]([NH:8][CH2:9][C:10]([O:12]C)=[O:11])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:15]>CO>[C:1]1([C:6]([NH:8][CH2:9][C:10]([O-:12])=[O:11])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[Na+:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 531395HCID 531395, compound

Product 1

HCID 23706078HCID 23706078, compoundYield 103.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 200 ml of a solution of 16.70 g of methyl 2-(2-thenoylamino)acetate in methanol, 20 ml of aqueous solution of 4.02 g sodium hydroxide was added, and heated to reflux for 30 minutes. The solvent was distilled off under reduced pressure. The residue was crystallized by addition of isopropanol to provide 18.03 g of the objective compound as pale yellow crystals.

Workup

  1. temperatureheated
  2. temperatureto reflux for 30 minutes
  3. distillationThe solvent was distilled off under reduced pressure
  4. customThe residue was crystallized by addition of isopropanol

Sources & evidence

ORD record
ord-b9617518d6cb43daab999e2a75aa624d
Source dataset
uspto-grants-2006_04
Patent number
US07030143B2

Reaction notes

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