Triethylamine → HCID 69529829, compound

HRID 1796416Notes

Reaction equation

HRID 1796416 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C.[CH2:23]([S:26](Cl)(=[O:28])=[O:27])[CH2:24][CH3:25]>C(Cl)Cl>[C:9]([OH:27])(=[O:8])[CH3:10].[CH2:9]([O:8][C:7]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:1][S:26]([CH2:23][CH2:24][CH3:25])(=[O:28])=[O:27])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 662791-Propanesulfonyl chlorideHCID 2405482-Benzyloxyaniline

Product 1

HCID 69529829HCID 69529829, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5.0 g (0.00194 mole) of 3-amino-4-benzyloxybenzene were mixed with 150 ml of methylene chloride in a nitrogen atmosphere and 3.3 ml (0.0236 mole) of triethylamine and 2.74 ml (0.0236 mole) of 1-propanesulfonyl chloride were added. It was stirred overnight at ambient temperature. It was washed with water, the two phases were separated and the organic phase was dried over sodium sulfate; it was filtered and the solvent was evaporated off under reduced pressure. The residue was taken up in isopropyl ether and the precipitate was filtered. The compound of the heading was obtained.

Workup

  1. additionwere added
  2. washIt was washed with water
  3. customthe two phases were separated
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. filtrationit was filtered
  6. customthe solvent was evaporated off under reduced pressure
  7. filtrationthe precipitate was filtered
  8. customThe compound of the heading was obtained

Sources & evidence

ORD record
ord-ad6088e7dd044baf9feb7b9b07b7d0d8
Source dataset
uspto-grants-2006_04
Patent number
US07030160B2

Reaction notes

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