Methylamine hydrochloride → HCID 22181383, compound

HRID 1796457Notes

Reaction equation

HRID 1796457 reaction equation
[CH2:1]([N:3]([CH2:16][CH3:17])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8](F)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2].Cl.[CH3:19][NH2:20]>CCO>[CH2:1]([N:3]([CH2:16][CH3:17])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([NH:20][CH3:19])=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 22181444N,N-diethyl-4-fluoro-3-nitrobenzamide

Product 1

HCID 22181383HCID 22181383, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

Following general procedure 2B: A mixture of N,N-diethyl-4-fluoro-3-nitrobenzamide (0.125 g, 0.521 mmol), methylamine hydrochloride (0.035 g, 0.521 mmol) in 80% aq. EtOH (3 mL) was heated at 85° C. for 4 hours. Usual work-up provided the title compound (0.130 g, 100%) which was used without further purification. MS (ESI) (M+H)+=252.

Sources & evidence

ORD record
ord-23425a4915a346afb4564aec7cc3c34a
Source dataset
uspto-grants-2006_04
Patent number
US07030139B2

Reaction notes

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