HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((Cyclopropylmethyl)amino)-3-nitrobenzonitrile → 3-amino-4-[(Cyclopropylmethyl)amino]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((Cyclopropylmethyl)amino)-3-nitrobenzonitrile | HCID 22181265 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-amino-4-[(Cyclopropylmethyl)amino]benzonitrile | HCID 22181399 | 95% |
Reaction Steps
Following the general procedure 2C, crude 4-[(cyclopropylmethyl)-amino]-3-nitrobenzonitrile (920 mg, 4.24 mmol) was hydrogenated for 2 h (35 psi) in 40 mL of EtOAc to yield 750 mg crude product (95%) and was used for the next step without further purification. MS (ESI) (M+H)+=188.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030139B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-ab72ea15eccd4ef5b3d792cbd9a07362 |
| Source note | uspto-grants-2006_04 |