Water → HCID 22181313, compound

HRID 1796493Notes

Reaction equation

HRID 1796493 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH:15]1([CH2:18][NH2:19])[CH2:17][CH2:16]1.O>C(O)C>[CH:15]1([CH2:18][NH:19][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 962WaterHCID 67694Acetamide, N-(4-fluoro-3-nitrophenyl)-HCID 75646Cyclopropanemethanamine

Product 1

HCID 22181313HCID 22181313, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following general procedure 2B: To a solution of N-(4-fluoro-3-nitrophenyl)acetamide (15.4 g, 77.7 mmol) in 80% aqueous ethanol (150 mL) was added cyclopropanemethylamine (10 mL) at room temperature. The reaction mixture was heated to reflux overnight. After cooling to room temperature, H2O (300 mL) was added and the desired product precipitated out as an orange solid (18 g, 92%).

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux overnight
  3. customthe desired product precipitated out as an orange solid (18 g, 92%)

Sources & evidence

ORD record
ord-58d80c9806ad48f4b3be2c2b9d9a8404
Source dataset
uspto-grants-2006_04
Patent number
US07030139B2

Reaction notes

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