HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 22181313, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetamide, N-(4-fluoro-3-nitrophenyl)- | HCID 67694 | — |
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22181313 | HCID 22181313 | — |
Reaction Steps
Following general procedure 2B: To a solution of N-(4-fluoro-3-nitrophenyl)acetamide (15.4 g, 77.7 mmol) in 80% aqueous ethanol (150 mL) was added cyclopropanemethylamine (10 mL) at room temperature. The reaction mixture was heated to reflux overnight. After cooling to room temperature, H2O (300 mL) was added and the desired product precipitated out as an orange solid (18 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07030139B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-58d80c9806ad48f4b3be2c2b9d9a8404 |
| Source note | uspto-grants-2006_04 |