HCID 21025099, compound → HCID 21025107, compound

Participants

Reaction Steps

4-Chloro-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester (5 mg, 0.019 mmol) and (4-Amino-phenol)-phenyl-acetonitrile (8 mg, 0.016 mmol) in DMF (0.5 ml) were heated at 110° C. for 3 hrs. The reaction mixture was purified by silica gel flash chromatography to isolate 3-cyano-4-[4-cyano-phenyl-methyl)phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 368 as yellow film (4.3 mg, 52%). [M+H]+=436.1.

Provenance & Evidence