HCID 21025099, compound → HCID 21025107, compound

HRID 1796604Notes

Reaction equation

HRID 1796604 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13](Cl)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2].[C:19]1([CH2:25][C:26]#[N:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[NH2:28][C:29]1[CH:34]=[CH:33][C:32](O)=[CH:31][CH:30]=1>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([CH:25]([C:26]#[N:27])[C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:31][CH:30]=3)=[C:12]([C:15]#[N:16])[CH:11]=[N:10][N:9]2[CH:17]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 21025099HCID 21025099, compoundHCID 69649327HCID 69649327, compound

Product 1

HCID 21025107HCID 21025107, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Chloro-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester (5 mg, 0.019 mmol) and (4-Amino-phenol)-phenyl-acetonitrile (8 mg, 0.016 mmol) in DMF (0.5 ml) were heated at 110° C. for 3 hrs. The reaction mixture was purified by silica gel flash chromatography to isolate 3-cyano-4-[4-cyano-phenyl-methyl)phenylamino]-5-methyl-pyrrolo[1,2-b]pyridazine-6-carboxylic acid ethyl ester 368 as yellow film (4.3 mg, 52%). [M+H]+=436.1.

Workup

  1. customThe reaction mixture was purified by silica gel flash chromatography

Sources & evidence

ORD record
ord-dd5023e1e5a94bf9a7501922b199e28b
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

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