(4-Aminophenoxy)benzene → HCID 21025087, compound

Participants

Reaction Steps

A solution of 2-(4-Chloro-3-cyano-6-ethoxycarbonyl-pyrrolo[1,2-b]pyridazin-5-ylmethyl)-malonic acid diethyl ester 369B (6.5 mg, 0.015 mmol) and 4-phenoxyphenylamine (4.2 mg, 0.023 mmol) in DMF (0.5 ml) was heated at 110° C. for 4 hrs. The reaction mixture was purified by silica gel flash chromatography to isolate 369 as a yellow film (1.7 mg, 20%). [M+H]+32 571.

Provenance & Evidence