(4-Aminophenoxy)benzene → HCID 21025087, compound

HRID 1796605Notes

Reaction equation

HRID 1796605 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH:5]([CH2:11][C:12]1[C:13]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:14][N:15]2[C:20]=1[C:19](Cl)=[C:18]([C:22]#[N:23])[CH:17]=[N:16]2)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2].[O:30]([C:37]1[CH:42]=[CH:41][C:40]([NH2:43])=[CH:39][CH:38]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:29])[CH:5]([CH2:11][C:12]1[C:13]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:14][N:15]2[C:20]=1[C:19]([NH:43][C:40]1[CH:39]=[CH:38][C:37]([O:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:42][CH:41]=1)=[C:18]([C:22]#[N:23])[CH:17]=[N:16]2)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 8764(4-Aminophenoxy)benzeneHCID 21025086HCID 21025086, compound

Product 1

HCID 21025087HCID 21025087, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-(4-Chloro-3-cyano-6-ethoxycarbonyl-pyrrolo[1,2-b]pyridazin-5-ylmethyl)-malonic acid diethyl ester 369B (6.5 mg, 0.015 mmol) and 4-phenoxyphenylamine (4.2 mg, 0.023 mmol) in DMF (0.5 ml) was heated at 110° C. for 4 hrs. The reaction mixture was purified by silica gel flash chromatography to isolate 369 as a yellow film (1.7 mg, 20%). [M+H]+32 571.

Workup

  1. customThe reaction mixture was purified by silica gel flash chromatography

Sources & evidence

ORD record
ord-a4c4cb07035040ce944ea2d5d030ff65
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

Loading…