反应详情

6-Amino-5-methyl-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile hydrochloride (9.5 mg, 0.024 mmol) and 2-chlorobenzothiazole (4.4 mg, 0.026 mmol) in DMF (0.1 ml) were stirred at 100° C. for 12 hrs. The reaction mixture was concentrated and purified by silica gel flash chromatography to isolate 379 as a yellow film (3.3 mg, 28%). [M+H]+489.14

1. concentrationThe reaction mixture was concentrated
2. custompurified by silica gel flash chromatography