Dimethylformamide dimethyl acetal → 1-(dimethylamino-methyleneamino)-1H-pyrrole-2,5-dicarboxylic acid diethyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 406C (482 mg, 2.13 mmol) and dimethoxymethyl-dimethyl-amine (1.5 ml) in anhydrous DMF (5 ml) was heated at 105° C. overnight. After the solvent was removed, the residue was purified by silica gel flash column chromatography to give 406D (546 mg, 91%) as pink crystals (25% EtOAc—hexanes). MS Found: (M+H)+=282.1

Herkunft & Nachweise