Dimethylformamide dimethyl acetal → 1-(dimethylamino-methyleneamino)-1H-pyrrole-2,5-dicarboxylic acid diethyl ester

HRID 1796645노트

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HRID 1796645 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]([NH2:16])[C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:10]=1)=[O:5])[CH3:2].CO[CH:19]([N:22]([CH3:24])[CH3:23])OC>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[N:7]([N:16]=[CH:19][N:22]([CH3:24])[CH3:23])[C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:9][CH:10]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 21025082diethyl 1-amino-1H-pyrrole-2,5-dicarboxylate

생성물 1

HCID 693265321-(dimethylamino-methyleneamino)-1H-pyrrole-2,5-dicarboxylic acid diethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
105 °C

실험 절차

A mixture of 406C (482 mg, 2.13 mmol) and dimethoxymethyl-dimethyl-amine (1.5 ml) in anhydrous DMF (5 ml) was heated at 105° C. overnight. After the solvent was removed, the residue was purified by silica gel flash column chromatography to give 406D (546 mg, 91%) as pink crystals (25% EtOAc—hexanes). MS Found: (M+H)+=282.1

후처리

  1. customAfter the solvent was removed
  2. customthe residue was purified by silica gel flash column chromatography

출처 및 근거

ORD 기록
ord-3174ea1335284ad7a6ff65c62c46cae0
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030112B2

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