Acetic Anhydride → HCID 22179524, compound

HRID 1796655Notes

Reaction equation

HRID 1796655 reaction equation
[CH2:1]([NH:8][CH2:9][C:10]1[C:11]([CH3:35])=[C:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[CH:21][CH:20]=3)=[C:16]([C:32]#[N:33])[CH:15]=[N:14][N:13]2[CH:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(CC)CC.[CH3:43][C:44](OC(C)=O)=[O:45]>C(Cl)Cl>[CH2:1]([N:8]([CH2:9][C:10]1[C:11]([CH3:35])=[C:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)=[CH:21][CH:20]=3)=[C:16]([C:32]#[N:33])[CH:15]=[N:14][N:13]2[CH:34]=1)[C:44](=[O:45])[CH3:43])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 22179730HCID 22179730, compound

Product 1

HCID 22179524HCID 22179524, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 414A (28 mg, 0.06 mmol) and Et3N (17 μl, 0.12 mmol) in CH2Cl2 (2 ml) was added Ac2O (11 μl, 0.12 mmol), reaction completed immediately. After regular workup, the residue was purified by prep. TLC to give the 414 (25 mg, 83%) as light yellow powder (2% MeOH—CHCl3). It has a retention time of 7.23 min (standard LCl method, 8 min run). MS Found: (M+H)+=502.0

Workup

  1. customAfter regular workup, the residue was purified by prep

Sources & evidence

ORD record
ord-fe4f9f2bcc9445378b79de641f92f284
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

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