Guaiacol → o-(p-Nitrophenoxy)anisole

HRID 1796673Notes

Reaction equation

HRID 1796673 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19].[N+](C1C=CC(OC2C=CC=CC=2)=CN=1)([O-])=O>>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 460GuaiacolHCID 9590p-FluoronitrobenzeneHCID 221794212-Nitro-5-phenoxypyridine

Product 1

HCID 122965o-(p-Nitrophenoxy)anisoleYield 100%

Procedure

Compound 430A (7.34 g, 100%) was prepared from 1-fluoro-4-nitro-benzene (4.23 g, 30.0 mmol) and 2-methoxy-phenol (3.72 g, 30.0 mmol) by a route analogous to that used for the preparation of compound 429B. It is a bright yellow solid.

Sources & evidence

ORD record
ord-86832e88be114c8e8d489a7511263b54
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

Loading…