Methyl alpha-hydroxyisobutyrate → 2-Methyl-2-[2-(4-nitro-phenoxy)-phenoxy]-propionic Acid Methyl Ester

HRID 1796682Notes

Reaction equation

HRID 1796682 reaction equation
C(OC(C1NC=C(C(OCC)=O)C=1C)=O)C.OC(C)(C)C(OC)=O.[C:25]([O:29][C:30](=[O:51])[C:31]([CH3:50])([O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[O:40][C:41]1[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][CH:42]=1)[CH3:32])(C)(C)C>>[CH3:25][O:29][C:30](=[O:51])[C:31]([CH3:32])([O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[O:40][C:41]1[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][CH:42]=1)[CH3:50]

Participants

4

Reactant 3

HCID 75024Methyl alpha-hydroxyisobutyrateHCID 226731Diethyl 3-methyl-1h-pyrrole-2,4-dicarboxylateHCID 210251752-Methyl-2-[2-(4-nitro-phenoxy)-phenoxy]-propionic acid tert-butyl ester

Product 1

HCID 210251532-Methyl-2-[2-(4-nitro-phenoxy)-phenoxy]-propionic Acid Methyl EsterYield 98%

Procedure

Compound 433A (5.63 g, 98%) was prepared from 1A (4.00 g, 17.3 mmol) and methyl 2-hydroxyisobutyrate (5.00 ml, 43.3 mmol) by a route analogous to that used for the preparation of compound 388B. It is a faintly yellow solid.

Sources & evidence

ORD record
ord-b20a6fce9a5f4093946362fd0a85aeee
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

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