2-Amino-2-methyl-1-propanol → 2-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

HRID 1796732Notes

Reaction equation

HRID 1796732 reaction equation
C(O[C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])C.[NH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19]>C1(C)C=CC=CC=1>[OH:19][CH2:18][C:17]([NH:16][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:11](=[O:12])[O:10][CH2:9]2)=[O:5])([CH3:21])[CH3:20]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 90088Ethyl 1,3-dihydro-1-oxoisobenzofuran-5-carboxylate

Product 1

HCID 111960052-[[(1-Oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl]amino]-2-methyl-1-propanol

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Method B): 5-Ethoxycarbonylphthalid (82 g, 0.4 mole) is added to a solution of 2-amino-2-methylpropan-1-ol (44.6 g. 0.5 mole) in toluene (100 ml). The mixture is heated to reflux temperature for 24 hours. Upon cooling the title compound is filtered off and recrystallised from hot toluene.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux temperature for 24 hours

Sources & evidence

ORD record
ord-c5c38f33c78543418c5811b599003618
Source dataset
uspto-grants-2006_04
Patent number
US07030252B2

Reaction notes

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