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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1796738Generated: November 3, 2026

2,2,2-Trifluoroethylamine hydrochloride → 3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide

https://huagongshe.com/reaction/1796738

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2,2-Trifluoroethylamine hydrochlorideHCID 9772—
Reactant3-[4-(3,3-Diphenyl-1-propyl)piperazin-1-yl]benzoic acidHCID 22180487—
Product3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamideHCID 22180639—

Reaction Steps

The procedure of step (d) of Example 1 was repeated using the compound prepared in step (c) of Example 1, except that 2,2,2-trifluoroethylamine hydrochloride was used instead of N-methylbenzylamine. Thus, 3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide was prepared.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07030120B2
Source datasetuspto-grants-2006_04
ORD IDord-d1435a67fc26428b82cf4c91d4934c31
Source noteuspto-grants-2006_04