tert-Butyl piperazine-1-carboxylate → HCID 69591932, compound

HRID 1796753Notes

Reaction equation

HRID 1796753 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1F)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:14]([O:18][C:19]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[F:1][C:2]1[C:3]([CH2:3][CH2:2][CH2:12][CH2:11][N:24]2[CH2:25][CH2:26][N:21]([C:19]([O:18][C:14]([CH3:17])([CH3:15])[CH3:16])=[O:20])[CH2:22][CH2:23]2)=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 2737171Ethyl 3,4-difluorobenzoate

Product 1

HCID 69591932HCID 69591932, compound

Procedure

Step (c) of Example 75 was repeated, except that the compound prepared in step (a) of Example 81 was used and 4-(t-butoxycarbonyl)piperazine was used instead of 4-(3,3-diphenyl-1-propyl)piperazine. Thus, ethyl 3-fluoro-[4-[4-(t-butoxycarbonyl)piperazin-1-yl]butyl]-benzoate was prepared.

Sources & evidence

ORD record
ord-e0371f82be2d42228e4e5eee9fca7334
Source dataset
uspto-grants-2006_04
Patent number
US07030120B2

Reaction notes

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