7-piperazinyl-2-(pyridin-2-yl)methyl-2H-phthalazin-1-one → 2-(Pyridin-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]-2H-phthalazin-1-one

HRID 1796776Notes

Reaction equation

HRID 1796776 reaction equation
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[N:27]1([C:33]2[CH:42]=[C:41]3[C:36]([CH:37]=[N:38][N:39]([CH2:44][C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][N:46]=4)[C:40]3=[O:43])=[CH:35][CH:34]=2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[N:46]1[CH:47]=[CH:48][CH:49]=[CH:50][C:45]=1[CH2:44][N:39]1[N:38]=[CH:37][C:36]2[C:41](=[CH:42][C:33]([N:27]3[CH2:32][CH2:31][N:30]([CH2:23][CH2:22][CH2:21][C:7]4([C:5](=[O:6])[NH:4][CH2:3][C:2]([F:26])([F:25])[F:1])[C:20]5[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=5[O:14][C:13]5[C:8]4=[CH:9][CH:10]=[CH:11][CH:12]=5)[CH2:29][CH2:28]3)=[CH:34][CH:35]=2)[C:40]1=[O:43]

Participants

3

Reactant 2

HCID 221802937-piperazinyl-2-(pyridin-2-yl)methyl-2H-phthalazin-1-oneHCID 221805833-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl bromide

Product 1

HCID 221804552-(Pyridin-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]-2H-phthalazin-1-one

Procedure

Step (b) of Example 92 was repeated, except that the compound prepared in step (b) of Example 114 and the compound prepared in step (c) of Example 143 were used as the starting compounds. Thus, the title compound was obtained.

Sources & evidence

ORD record
ord-0e9f8e1cad864c82acb326cf83a4082b
Source dataset
uspto-grants-2006_04
Patent number
US07030120B2

Reaction notes

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