HRID1796782

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(NCC(F)(F)F)C1(CCCBr)c2ccccc2Oc2ccccc21

HCID22180583

未命名化合物

HCID22180591

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cccc(N2CCN(CCCC3(C(=O)NCC(F)(F)F)c4ccccc4Oc4ccccc43)CC2)c1C

HCID22180646

未命名化合物

PROCEDURE

实验过程

Step (b) of Example 1 was repeated, except that the compound prepared in step (a) of Example 53 and the compound prepared in step (b) of Example 114 were used as the starting compounds. Thus, ethyl 2-methyl-3-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-xanthen-9-yl]propyl]piperazin-1-yl]benzoate was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5a44142f599645e58aecd2b8732a4461
来源数据集: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07030120B2
来源说明: uspto-grants-2006_04

反应 SMILES

[CH3:1][C:2]1[C:12]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[F:19][C:20]([F:44])([F:43])[CH2:21][NH:22][C:23]([C:25]1([CH2:39][CH2:40][CH2:41]Br)[C:38]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[O:32][C:31]2[C:26]1=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:24]>>[CH3:1][C:2]1[C:12]([N:13]2[CH2:14][CH2:15][N:16]([CH2:41][CH2:40][CH2:39][C:25]3([C:23](=[O:24])[NH:22][CH2:21][C:20]([F:44])([F:19])[F:43])[C:38]4[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=4[O:32][C:31]4[C:26]3=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:17][CH2:18]2)=[CH:11][CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]