HCID 69588602, compound → HCID 11775765, compound

HRID 1796865Notes

Reaction equation

HRID 1796865 reaction equation
C(OC([NH:8][C@H:9]([CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C@H:10]([OH:14])[C:11]([OH:13])=[O:12])=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][C@H:9]([CH2:15][CH2:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C@H:10]([OH:14])[C:11]([OH:13])=[O:12]

Participants

4

Reactant 1

HCID 69588602HCID 69588602, compound

Product 1

HCID 11775765HCID 11775765, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 9D (25.7 mg, 0.08 mmol) in 4M HCl in dioxane (2 mL) was stirred at room temperature for 1 hour and concentrated to provide the desired product. MS (ESI) m/e 224 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 7.29 (m, 2H), 7.18 (m, 3H), 4.11 (d, 1H), 3.69 (m, 1H), 2.57 (m, 2H), 1.73–1.49 (m, 4H).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-30c89ef5ed054b0fbe1fece8fdee8ae2
Source dataset
uspto-grants-2006_04
Patent number
US07030262B2

Reaction notes

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