HCID 91551587, compound → HCID 10442600, compound

HRID 1796869Notes

Reaction equation

HRID 1796869 reaction equation
C(OC([NH:8][C@H:9]([CH2:16][CH2:17][S:18][CH3:19])[CH:10]([OH:15])[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][C@H:9]([CH2:16][CH2:17][S:18][CH3:19])[CH:10]([OH:15])[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 91551587HCID 91551587, compound

Product 1

HCID 10442600HCID 10442600, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of Example 11C in 4M HCl in dioxane (10 mL) at room temperature was stirred for 4 hours and concentrated to provide the desired product. MS (APCI(+)) m/e 194 (M−H)−; 1H NMR (300 MHz, DMSO-d6) δ 8.09 (br s, 2H), 7.94 (br s, 1H), 6.58 (m, 0.5H), 6.42 (m, 0.5H), 4.48 (m, 0.5H), 4.30 (m, 0.5H), 3.72 (s, 3H), 2.58 (m, 2H), 2.04 (s, 1.5H), 2.02 (s, 1.5H), 1.82 (m, 2H).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-ada714623f4749a78c51c94bdbff051b
Source dataset
uspto-grants-2006_04
Patent number
US07030262B2

Reaction notes

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