HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 2-{2-[(4-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Bromo-2-fluorobenzaldehyde | HCID 143517 | — |
| Reactant | 1-(4-Bromo-2-fluoro-benzylidene)-pyrrolidinium chloride | HCID 17912268 | — |
| Reactant | 4-Pyrrol-1-yl-methyl-pyridine | HCID 22174758 | — |
| Product | 2-{2-[(4-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine | HCID 10158696 | — |
Reaction Steps
The preparation was carried out in accordance with general synthesis instructions 4 from 4-pyrrol-1-yl-methyl-pyridine and 1-(4-bromo-2-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 4-bromo-2-fluorobenzaldehyde and pyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07034018B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-09b9a1465ff24fe1b0732087274cf277 |
| Source note | uspto-grants-2006_04 |