Pyrrolidine → 2-{2-[(4-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine

HRID 1796931Notes

Reaction equation

HRID 1796931 reaction equation
[N:1]1([C:6]2C=CN=[C:8]([CH3:12])[CH:7]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[Br:14][C:15]1[CH:26]=[CH:25][C:18]([CH:19]=[N+:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=[C:17]([F:27])[CH:16]=1.BrC1C=CC(C=O)=C(F)C=1.[NH:38]1CC[CH2:40][CH2:39]1>>[Br:14][C:15]1[CH:26]=[CH:25][C:18]([CH:19]([N:20]2[CH2:21][CH2:22][CH2:23][CH2:24]2)[C:5]2[N:1]([CH2:6][C:7]3[CH:8]=[CH:12][CH:40]=[CH:39][N:38]=3)[CH:2]=[CH:3][CH:4]=2)=[C:17]([F:27])[CH:16]=1

Participants

5

Reactant 4

HCID 31268PyrrolidineHCID 1435174-Bromo-2-fluorobenzaldehydeHCID 179122681-(4-Bromo-2-fluoro-benzylidene)-pyrrolidinium chlorideHCID 221747584-Pyrrol-1-yl-methyl-pyridine

Product 1

HCID 101586962-{2-[(4-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 4-pyrrol-1-yl-methyl-pyridine and 1-(4-bromo-2-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 4-bromo-2-fluorobenzaldehyde and pyrrolidine.

Sources & evidence

ORD record
ord-09b9a1465ff24fe1b0732087274cf277
Source dataset
uspto-grants-2006_04
Patent number
US07034018B2

Reaction notes

Loading…