Pyrrolidine → 2-{2-[(3-Bromo-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine

HRID 1796935Notes

Reaction equation

HRID 1796935 reaction equation
[N:1]1([C:6]2C=CN=[C:8]([CH3:12])[CH:7]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[Br:14][C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][CH:26]=1)[CH:18]=[N+:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.BrC1C=C(C=CC=1)C=O.[NH:36]1CC[CH2:38][CH2:37]1>>[Br:14][C:15]1[CH:16]=[C:17]([CH:18]([N:19]2[CH2:20][CH2:21][CH2:22][CH2:23]2)[C:5]2[N:1]([CH2:6][C:7]3[CH:8]=[CH:12][CH:38]=[CH:37][N:36]=3)[CH:2]=[CH:3][CH:4]=2)[CH:24]=[CH:25][CH:26]=1

Participants

5

Reactant 4

HCID 31268PyrrolidineHCID 765833-BromobenzaldehydeHCID 179123141-(3-Bromo-benzylidene)-pyrrolidinium chlorideHCID 221747584-Pyrrol-1-yl-methyl-pyridine

Product 1

HCID 101788522-{2-[(3-Bromo-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 4-pyrrol-1-yl-methyl-pyridine and 1-(3-bromo-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 3-bromobenzaldehyde and pyrrolidine.

Sources & evidence

ORD record
ord-2b475e3672584fcdb9be8ee84bc0b4e3
Source dataset
uspto-grants-2006_04
Patent number
US07034018B2

Reaction notes

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