Pyrrolidine → 2-{2-[(3-Bromo-4-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-ylmethyl}-pyridine
Reaction equation
[N:1]1([C:6]2C=CN=[C:8]([CH3:12])[CH:7]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[Br:14][C:15]1[CH:16]=[C:17]([CH:24]=[CH:25][C:26]=1[F:27])[CH:18]=[N+:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.BrC1C=C(C=CC=1F)C=O.[NH:38]1CC[CH2:40][CH2:39]1>>[Br:14][C:15]1[CH:16]=[C:17]([CH:18]([N:19]2[CH2:20][CH2:21][CH2:22][CH2:23]2)[C:5]2[N:1]([CH2:6][C:7]3[CH:8]=[CH:12][CH:40]=[CH:39][N:38]=3)[CH:2]=[CH:3][CH:4]=2)[CH:24]=[CH:25][C:26]=1[F:27]Participants
5
Procedure
The preparation was carried out in accordance with general synthesis instructions 4 from 4-pyrrol-1-yl-methyl-pyridine and 1-(3-bromo-4-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 3-bromo-4-fluorobenzaldehyde and pyrrolidine.
Sources & evidence
- ORD record
- ord-a70994ce8409470c8039ab8aceeb97ae
- Source dataset
- uspto-grants-2006_04
- Patent number
- US07034018B2
Reaction notes
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