Hydrochloric Acid → HCID 22174798, compound

HRID 1796956Notes

Reaction equation

HRID 1796956 reaction equation
C([NH:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])=[O:14])=[CH:9][CH:8]=1)([CH3:6])[CH3:5])=O.O.Cl>C(O)(=O)C>[NH2:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:16])=[O:14])=[CH:9][CH:8]=1)([CH3:5])[CH3:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 22174799HCID 22174799, compound

Product 1

HCID 22174798HCID 22174798, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4(2-formamidoprop-2-yl)-benzil, prepared as described in Step 6 (6.17 g) was dissolved in 100 ml of glacial acetic acid, 84 ml of water and 6 ml of concentrated HCl. The mixture was stirred at reflux for 3 hours and then the solvent removed under vacuum at 60 C. The residue was converted to the free based form, extracted with organic solvent, washed with water, dried and concentrated to provide the title compound as an oil.

Workup

  1. temperatureat reflux for 3 hours
  2. customthe solvent removed under vacuum at 60 C
  3. extractionextracted with organic solvent
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-e90839ee8e724e57a4955bd01fb553fa
Source dataset
uspto-grants-2006_04
Patent number
US07034026B2

Reaction notes

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