Hydrochloric Acid → HCID 91666795, compound

Participants

Reaction Steps

A mixture of 5-[2-(tetrahydro-pyran-2-yloxy)ethyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (0.80 mmol, 2.4 mmol) and aqueous hydrochloric acid (2 mL, 2N) in ethanol (10 mL) was stirred under reflux for one hour and then evaporated under reduced pressure to yield crude (1S,4S)-2-(2,5-Diazabicyclo[2.2.1]hept-2-yl)ethanol, dihydrochloride (0.51 g) as a dark oil which was used in the next step without further purification.

Provenance & Evidence