Hydrochloric Acid → HCID 91666795, compound

HRID 1796972Notes

Reaction equation

HRID 1796972 reaction equation
C(OC([N:8]1[CH2:13][CH:12]2[CH2:14][CH:9]1[CH2:10][N:11]2[CH2:15][CH2:16][O:17]C1CCCCO1)=O)(C)(C)C.[ClH:24]>C(O)C>[ClH:24].[ClH:24].[C@H:12]12[CH2:14][C@H:9]([NH:8][CH2:13]1)[CH2:10][N:11]2[CH2:15][CH2:16][OH:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69583658HCID 69583658, compound

Product 1

HCID 91666795HCID 91666795, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-[2-(tetrahydro-pyran-2-yloxy)ethyl]-2,5-diazabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (0.80 mmol, 2.4 mmol) and aqueous hydrochloric acid (2 mL, 2N) in ethanol (10 mL) was stirred under reflux for one hour and then evaporated under reduced pressure to yield crude (1S,4S)-2-(2,5-Diazabicyclo[2.2.1]hept-2-yl)ethanol, dihydrochloride (0.51 g) as a dark oil which was used in the next step without further purification.

Workup

  1. temperatureunder reflux for one hour
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-da3b2b60d025439495dee2da5af57136
Source dataset
uspto-grants-2006_04
Patent number
US07034016B2

Reaction notes

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