Pyridine → HCID 77778974, compound

HRID 1796985Notes

Reaction equation

HRID 1796985 reaction equation
[C:1]1([CH:7]2[CH2:9][CH:8]2[NH:10][C:11]2[C:12]3[N:23]=[N:22][N:21]([CH:24]4[CH2:28][CH:27]([OH:29])[CH:26]=[CH:25]4)[C:13]=3[N:14]=[C:15]([S:17][CH2:18][CH2:19][CH3:20])[N:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.C(Cl)(=[O:38])C>CN(C)C1C=CN=CC=1.ClCCl>[C:1]1([CH:7]2[CH2:9][CH:8]2[NH:10][C:11]2[C:12]3[N:23]=[N:22][N:21]([CH:24]4[CH2:25][CH2:26][CH:27]([OH:29])[CH:28]4[OH:38])[C:13]=3[N:14]=[C:15]([S:17][CH2:18][CH2:19][CH3:20])[N:16]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 131725713HCID 131725713, compound

Product 1

HCID 77778974HCID 77778974, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of the product of step d) (0.78 g), pyridine (0.43 ml) and 4-dimethylaminopyridine (1 mg) in dichloromethane (15 ml) was added acetyl chloride (0.16 ml). The solution was stirred for 3 hours and then concentrated in vacuo. The residue was purified by chromatography (SiO2, ethyl acetate:hexane 1:1 as eluant) to afford the sub-title compound (0.75 g).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by chromatography (SiO2, ethyl acetate:hexane 1:1 as eluant)

Sources & evidence

ORD record
ord-43dd7f1ca6bf4fe1b3250e43e8372267
Source dataset
uspto-grants-2006_04
Patent number
US07034032B2

Reaction notes

Loading…