Tartrate → HCID 77679381, 화합물

HRID 1796990노트

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HRID 1796990 반응식
Cl[C:2]1[C:3]2[N:14]=[N:13][N:12]([C@@H:15]3[CH2:19][CH2:18][CH2:17][C@H:16]3[OH:20])[C:4]=2[N:5]=[C:6]([S:8][CH2:9][CH2:10][CH3:11])[N:7]=1.[F:21][C:22]1[CH:23]=[C:24]([C@@H:29]2[CH2:31][C@H:30]2[NH2:32])[CH:25]=[CH:26][C:27]=1[F:28].O[C@H]([C@@H](O)C([O-])=O)C([O-])=O>>[F:21][C:22]1[CH:23]=[C:24]([CH:29]2[CH2:31][CH:30]2[NH:32][C:2]2[C:3]3[N:14]=[N:13][N:12]([CH:15]4[CH2:19][CH2:18][CH2:17][CH:16]4[OH:20])[C:4]=3[N:5]=[C:6]([S:8][CH2:9][CH2:10][CH3:11])[N:7]=2)[CH:25]=[CH:26][C:27]=1[F:28]

참가 물질

4

반응물 3

HCID 119400TartrateHCID 9834068(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHCID 87885146rel-(1R,2R)-2-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]cyclopentanol

생성물 1

HCID 77679381HCID 77679381, 화합물

실험 절차

Prepared using the product from Example 13 step b) (0.15 g) and (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (0.20 g) (prepared as described in WO 9905143) by the method of Example 13, step c). Purified by chromatography (SiO2, ethyl acetate:dichloromethane 1:9 as eluant) to afford the title (0.12 g).

후처리

  1. customPrepared
  2. customPurified by chromatography (SiO2, ethyl acetate:dichloromethane 1:9 as eluant)
  3. customto afford the title (0.12 g)

출처 및 근거

ORD 기록
ord-9862e648a30d4c6782e8286073b8825d
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07034032B2

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