Trifluoroacetic acid → (4,4-Difluorocyclohexyl)amine

Temperature

0 °C

A solution of N-(4,4-difluorocyclohexyl)(t-butoxy)carboxamide (6.51 mmol) in CH2Cl2 (20 mL) was treated with TFA (10 mL) at room temperature. The reaction mixture was stirred for 2 hours, the solvent was removed in vacuo, and the crude product was dissolved in water and washed with chloroform. The acidic aqueous phase was cooled at 0° C. and made basic by the addition of solid KOH. The resulting mixture was extracted with CH2Cl2, dried, and filtered yielding the title compound which was used without further purification as a 0.3 M solution in CH2Cl2.

1. customthe solvent was removed in vacuo
2. dissolutionthe crude product was dissolved in water
3. washwashed with chloroform
4. additionmade basic by the addition of solid KOH
5. extractionThe resulting mixture was extracted with CH2Cl2
6. customdried
7. filtrationfiltered

ORD record

ord-de6d0d6d1ccd4862a094d83eeb618d55

Source dataset

uspto-grants-2006_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07034033B2