2-Methylpyridine 1-oxide → 2-[2-(4-Methoxy-phenyl)-vinyl]-pyridine 1-oxide

HRID 1797084Notes

Reaction equation

HRID 1797084 reaction equation
[N+:1]1([O-:8])[C:2]([CH3:7])=[CH:3][CH:4]=[CH:5][CH:6]=1.C([O-])(C)(C)C.[K+].[CH:15](=O)[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1>>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([CH:15]=[CH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N+:1]=2[O-:8])=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 136022-Methylpyridine 1-oxideHCID 312444-MethoxybenzaldehydeHCID 23665647Potassium tert-butoxide

Product 1

HCID 695921122-[2-(4-Methoxy-phenyl)-vinyl]-pyridine 1-oxide

Procedure

Following the general method described in example 2a, 2-picoline-1-oxide was reacted with potassium tert.-butanolate and p-anisaldehyde. After extraction and chromatography the title compound was obtained as a yellow solid material. MS: m/e=227 (M+).

Workup

  1. extractionAfter extraction and chromatography the title compound
  2. customwas obtained as a yellow solid material

Sources & evidence

ORD record
ord-85523bf095514b729dd6eac25ff07320
Source dataset
uspto-grants-2006_04
Patent number
US07034044B2

Reaction notes

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