Dimethyl Sulfate → HCID 69592008, compound

HRID 1797087Notes

Reaction equation

HRID 1797087 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N+:11]=2[O-])=[CH:4][CH:3]=1.COS(OC)(=O)=O.[C-:24]#[N:25].[Na+]>C(O)(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[N:11]=[C:12]([C:24]#[N:25])[CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 8929Sodium CyanideHCID 69592014HCID 69592014, compound

Product 1

HCID 69592008HCID 69592008, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Following the general method described in example 2b, 2-[2-(4-chloro-phenyl)-vinyl]-pyridine 1-oxide was reacted first with dimethylsulfate and then with NaCN. After extraction and crystallization the title compound was obtained as a beige crystalline material. Mp. 113–115° C. (isopropanol), MS: m/e=240 (M+).

Workup

  1. extractionAfter extraction and crystallization the title compound
  2. customwas obtained as a beige crystalline material

Sources & evidence

ORD record
ord-294413c5fc4643749862b6626609901c
Source dataset
uspto-grants-2006_04
Patent number
US07034044B2

Reaction notes

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