Dimethyl Sulfate → HCID 69592064, compound

HRID 1797096Notes

Reaction equation

HRID 1797096 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N+:12]=2[O-])[CH:6]=[CH:7][CH:8]=1.COS(OC)(=O)=O.[C-:27]#[N:28].[Na+]>>[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]2[N:12]=[C:13]([C:27]#[N:28])[CH:14]=[CH:15][CH:16]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 6497Dimethyl SulfateHCID 8929Sodium CyanideHCID 69592095HCID 69592095, compound

Product 1

HCID 69592064HCID 69592064, compound

Procedure

Following the general method described in example 2b, 2-[2-(3-trifluoromethyl-phenyl)-vinyl]-pyridine 1-oxide was reacted first with dimethylsulfate and then with NaCN. After extraction and chromatography (SiO2 with CH2Cl2/MeOH=97/3) the title compound was obtained as a yellow oil and directly used in the next step.

Workup

  1. extractionAfter extraction and chromatography (SiO2 with CH2Cl2/MeOH=97/3) the title compound
  2. customwas obtained as a yellow oil

Sources & evidence

ORD record
ord-252000636c3a47239a408b8af1d818bd
Source dataset
uspto-grants-2006_04
Patent number
US07034044B2

Reaction notes

Loading…