Dimethyl Sulfate → HCID 22176442, compound

HRID 1797101Notes

Reaction equation

HRID 1797101 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[CH:4][N+:3]=1[O-].COS(OC)(=O)=O.[C-:24]#[N:25].[Na+]>>[CH3:1][C:2]1[N:3]=[C:4]([C:24]#[N:25])[CH:5]=[C:6](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 6497Dimethyl SulfateHCID 8929Sodium CyanideHCID 69592084HCID 69592084, compound

Product 1

HCID 22176442HCID 22176442, compound

Procedure

Following the general method described in example 2b, 2-methyl-4-styryl-pyridine 1-oxide was reacted first with dimethylsulfate and then with NaCN. After extraction and chromatography (SiO2 with CH2Cl2) the title compound was obtained as a yellow crystalline material. MS: m/e=220 (M+).

Workup

  1. extractionAfter extraction and chromatography (SiO2 with CH2Cl2) the title compound
  2. customwas obtained as a yellow crystalline material

Sources & evidence

ORD record
ord-e68c1934d4f84d449381c7cc102c3907
Source dataset
uspto-grants-2006_04
Patent number
US07034044B2

Reaction notes

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