HCID 69617874, compound → HCID 69617814, compound

HRID 1797156Notes

Reaction equation

HRID 1797156 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][O:7][C:6]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=1)=[O:4].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][O:7][C:6]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=1)=[O:4]

Participants

5

Reactant 2

HCID 69617874HCID 69617874, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69617814HCID 69617814, compoundYield 85.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-(3-nitrophenyl)furan-3-carboxylic acid methyl ester (1.0 g) in methanol (60 mL) containing 10% palladium on carbon (2.9 g) was stirred under 1 atmosphere of hydrogen for 1 h. The reaction mixture was then filtered through Celite. Removal of the solvent at reduced pressure gave the title compound as a yellow solid (0.75 g). C12H11NO3: M+Na+ 240

Workup

  1. filtrationThe reaction mixture was then filtered through Celite
  2. customRemoval of the solvent at reduced pressure

Sources & evidence

ORD record
ord-76889fc5e3734590bad6d8399b7cdac6
Source dataset
uspto-grants-2006_04
Patent number
US07034053B2

Reaction notes

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