Hydrochloric Acid → HCID 23567019, compound

Participants

Reaction Steps

To a solution of {4′-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)-ethyl]-3-nitro-biphenyl-4-yl}-acetic acid ethyl ester. (0.341 g, 0.731 mmol, prepared in example 47) in Ethanol (5.0 mL) is added a solution of 6.7% NaOH (15.0 mL) and the resulting mixture is stirred under N2 at ambient temperature for 72 h. The mixture is diluted with H2O (100 mL) and acidified with 37% HCl. Extraction with EtOAc followed by drying (MgSO4), filtration, and evaporation of the filtrate in vacuo gives the title compound.

Provenance & Evidence