Hydrochloric Acid → HCID 23567019, compound

HRID 1797213Notes

Reaction equation

HRID 1797213 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:28])([CH3:27])[CH2:19][NH:20][S:21]([CH:24]([CH3:26])[CH3:25])(=[O:23])=[O:22])=[CH:14][CH:13]=2)=[CH:8][C:7]=1[N+:29]([O-:31])=[O:30])C.[OH-].[Na+].Cl>C(O)C.O>[F:28][C:18]([C:15]1[CH:14]=[CH:13][C:12]([C:9]2[CH:10]=[CH:11][C:6]([CH2:5][C:4]([OH:32])=[O:3])=[C:7]([N+:29]([O-:31])=[O:30])[CH:8]=2)=[CH:17][CH:16]=1)([CH3:27])[CH2:19][NH:20][S:21]([CH:24]([CH3:25])[CH3:26])(=[O:22])=[O:23]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23567032HCID 23567032, compound

Product 1

HCID 23567019HCID 23567019, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of {4′-[1-fluoro-1-methyl-2-(propane-2-sulfonylamino)-ethyl]-3-nitro-biphenyl-4-yl}-acetic acid ethyl ester. (0.341 g, 0.731 mmol, prepared in example 47) in Ethanol (5.0 mL) is added a solution of 6.7% NaOH (15.0 mL) and the resulting mixture is stirred under N2 at ambient temperature for 72 h. The mixture is diluted with H2O (100 mL) and acidified with 37% HCl. Extraction with EtOAc followed by drying (MgSO4), filtration, and evaporation of the filtrate in vacuo gives the title compound.

Workup

  1. extractionExtraction with EtOAc
  2. customby drying
  3. filtration(MgSO4), filtration, and evaporation of the filtrate in vacuo

Sources & evidence

ORD record
ord-172cc3b7beac4d98a4056960e863a923
Source dataset
uspto-grants-2006_04
Patent number
US07034045B1

Reaction notes

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