6-Amino-1-hexanol → HCID 22174482, compound

HRID 1797325Notes

Reaction equation

HRID 1797325 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])=[C:19]([Cl:32])[CH:18]=2)=[C:6]([NH:8][C:9](=[O:15])[CH2:10][CH2:11][C:12](O)=[O:13])[CH:7]=1.[NH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][OH:40]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[O:31])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])=[C:19]([Cl:32])[CH:18]=2)=[C:6]([NH:8][C:9](=[O:15])[CH2:10][CH2:11][C:12]([NH:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][OH:40])=[O:13])[CH:7]=1

Participants

3

Reactant 2

HCID 199606-Amino-1-hexanolHCID 22174490HCID 22174490, compound

Product 1

HCID 22174482HCID 22174482, compound

Procedure

The reaction and work up was conducted as described in the preparation of compound 205. Starting compounds were N-(5-bromo-2-{[3-chloro-4-(2-methylbenzoyl)phenyl]amino}phenyl)-succinamic acid (600 mg, 1.16 mmol) (prepared by a similar method as described in WO 01/05746) and 6-aminohexanol (151 mg, 1.28 mmol). The crude product was purified by flash chromatography using EtOAc as the eluent to afford the title compound as a yellow solid.

Workup

  1. customThe reaction and work
  2. customprepared by a similar method
  3. customThe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-c012bc23cf6f4cec8cb81c6e575149c8
Source dataset
uspto-grants-2006_04
Patent number
US07034015B2

Reaction notes

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